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ST&T Home > Client Services > Clinical Services > Immunoassay Services
Immunoassay Services

Scientists who specialize in allergic diseases and in the development of analytical methods, and instrumentation design to detect airborne allergen-antigen/antibody systems.

Environmental Monitoring of Protein Aeroallergens

The general principles of industrial hygiene apply in all respects to occupational allergens, just as they do for any airborne toxic agent.

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Differences in application of these general principles to occupational asthma arise from the requirement for specialized sampling and assay techniques and from the fact that only some workers are affected by the illness. Workers unfortunate enough to develop lung hypersensitivity to airborne antigens become ill upon exposure to very small concentrations of the agent, concentrations that have no effect on other workers. The methods of identifying the offending agents and the individual patients affected by occupational asthma are considered in other brochures.

Purpose of Air Sampling

Confirmation Of Exposure As Cause of Disease:
Identification of an occupation as being the source of occupational asthma has historically started with workers' or physicians' suspicions that asthma symptoms are temporally related to some occupation that uses a material that is a known or possible allergen. This suspicion is usually followed up by an epidemiologic survey of the workers that includes symptom diaries, spirometry, serial peak flow measurements, and skin or RAST tests for IgE antibody to the allergen. For investigation of individual cases, inhalation challenge tests are often added to confirm that the material that evoked IgE antibody to the allergen. For investigation of individual cases, inhalation challenge tests are often added to confirm that the material that evoked IgE antibody actually can cause an asthmatic response. A valuable additional, but often unused, link in the chain of evidence that a suspected allergen is the cause of occupational asthma is measurement of the allergen in the air at the worksite. Knowledge of the concentration encountered at work also allows correlation of the response of the worker to the inhalational challenge test in the laboratory to the exposure at work.

Monitoring The Worksite:
After changes to reduce the exposure have been made, a schedule of periodic air sampling is desirable to assure that the changes have been successful in achieving the goals. When the control strategy depends upon scheduled house-keeping, cleaning, or equipment maintenance, periodic monitoring is useful to assure that the program has not lapsed.


ANTIBODY SOURCE/TYPE ALLERGEN DESCRIPTION SPECIFICITY
     
MOUSE/MONOCLONAL
  DUST MITE:
Dermatophagoides farinae
GROUP I
GROUP II
D. pteronyssinus
GROUP I
GROUP II
Blomia tropicalis
CAT: Fel d1

COCKROACH:
GERMAN/AMERICAN (Bla qI)
GERMAN (Bla qII)

RAGWEED:
SHORT, GIANT, WESTERN


SPECIFIC
CROSS REACTIVE

SPECIFIC
CROSS REACTIVE
SPECIFIC
SPECIFIC


CROSS REACTIVE
SPECIFIC


CROSS REACTIVE
RABBIT/POLYCLONAL
  ENZYMES:
PAPAIN
SUBTILISNS

MISCELLANEOUS:
DOG
CAT
GRASSES
TREES
ASPERGILLUS
BASIDIOMYCETES
ALTERNARIA (MOLDS)
RAGWEED
INSECTS (MOTH)

SPECIFIC
VARIOUS


SPECIFIC
SPECIFIC
CROSS REACTIVE
SPECIFIC
SPECIFIC
VARIOUS
CROSS REACTIVE
CROSS REACTIVE
CROSS REACTIVE
HUMAN/IgE
  RODENTS:
RAT
MOUSE
GUINEA PIG

ENZYMES:
FICIN
SUBTILISNS

MISCELLANEOUS:
INSECTS
MITES (SEVERAL SPECIES)
DOG
CAT
LATEX (NATURAL RUBBER)
GRASSES
ASPERGUILLUS
RAGWEED
ALTERNARIA (MOLDS)

LOW MOLECULAR WEIGHT:
SOYBEAN
TREES

SPECIFIC
SPECIFIC
SPECIFIC


SPECIFIC
VARIOUS


CROSS REACTIVE
VARIOUS
SPECIFIC
SPECIFIC
SPECIFIC
CROSS REACTIVE
SPECIFIC
SPECIFIC
CROSS REACTIVE


SPECIFIC
VARIOUS
HUMAN/IgG
  BIRDS (ALL SPECIES)
HUMIDIFIER
ASPERGILLUS
ALMOND
alpha-AMYLASE
WHEAT GLUTEN
SPECIFIC
SPECIFIC
SPECIFIC
SPECIFIC
SPECIFIC
SPECIFIC

NOTE: THIS IS NOT AN ALL INCLUSIVE LIST AND CUSTOM ASSAYS CAN BE DESIGNED TO DETECT ANY ANTIGEN OF INTEREST. SEROLOGIC ASSAYS ARE ALSO AVALABLE UPON REQUEST.
 




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